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What comes after Evenity?

Osteoporosis & Bone Health | Last Active: 6 days ago | Replies (42)

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@wkay1212

What is your biggest concern about Prolia? I just finished my Evenity Injections and the plan for me is Prolia. I also have an issue with a stress fracture that is not healing.

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Replies to "What is your biggest concern about Prolia? I just finished my Evenity Injections and the plan..."

@wkay1212, I also have a stress fracture that is not healint, but I am taking Tymlos. Your experience is more evidence for me that the anabolics just help trabecular bones, especially the spine. Especially at first, I think they make cortical bones porous. I considered stopping the Tymlos to make my bone heal, but am afraid to do that without an absorptive medication.

My endo wants me to take Prolia after Tymlos, but I told him I don't want to. I am afraid of taking a medication that has side effects that could last a long time, and I don't want to take Prolia for the rest of my life.

Prolia causes a rebound effect when you stop it. Your bones go back to worse than baseline and fracture risk is increased. So you must stay on it forever (which, depending on your age, might be a reasonable course of action as long as you're not having any side effects that you can't live with) or take a bisphosphonate after going off Prolia. Whatever bone drug you take, whether antiresorptive or anabolic, is going to have side effects which you personally may or may not experience. If you decide to do Prolia, know what the side effects are and if the benefits for you outweigh the risks to you. Different people will answer that question differently. The main problem with Prolia is the rebound effect which is unique to that drug. If you find you can't tolerate it for some reason, you can't just stop it. You must take a relay bisphosphonate. Those have their own side effects to consider. You'll also have to consider what your insurance will cover. It's worth a discussion with your doctor for what the exit plan is for coming off Prolia.