1. < Osteoporosis & Bone Health

After bisphosphonates then what

Posted by serious @serious, Apr 16 1:51pm

I suspect many of us started on some form of bisphosphonate. My question is what did you do next after being on these drugs for many years? I am reading that the effects of Forteo/Tymlos, and Evenity are blunted. Did you move instead to Prolia or Reclast and then what happened?

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gently | @gently | Apr 24 12:39am
In reply to @mayblin "@gently, my head is spinning re vitd. Prior non vitD exposure resulted better response to an..." + (show)
@mayblin

@gently, my head is spinning re vitd. Prior non vitD exposure resulted better response to an anabolic? How does the mechanism work? Felt I have dyslexia here. I know the effect of teriparatide on blood calcium after injection. Could you explain in a different way, if you have time? Thanks a lot!

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mablin, some of the letters are missing; we entertain ourselves guessing the word.

Since D increases absorption of calcium from the intestine, we could speculate that the effect of PTHT appears blunted (in the ten of my sample) because D had already influenced the effect that PTHT enhances. PTH levels are lower in those with D deficiency; maybe those individuals benefit more from treatment with PTH.
It is easy to reach an induction fallacy with associative studies, but these studies yield great leads for investigations of cause.

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