Sometimes it does take docs awhile to tease this all out. And sometimes the docs know but don't explain it very well, leaving patients not really understanding what they have or the treatment goals. And sometimes the meds take time to work. My platelets got to 800, I took 1 cap hydroxyurea daily for a year and levels were still too high in 600s. The doc added three more caps per week and I have been "safe and stable" in 400s for 5 years. Hugs to you until this gets sorted out!