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Starting Esbreit (Pirfenidone)

Lung Health | Last Active: Jun 18, 2024 | Replies (26)

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Hubby's in his 3rd week with Pirfenidone now, and the increase to 3 pills 3 times a day seems to be causing stomach upset/tightness, as well as constant runny nose. These side effects were not a problem last week when he was taking "only" 2 pills 3 times a day.
He decided not to take his 3rd dose of 3 pills tonight, and is planning on cutitng back to the 2 pills 3 times a day dose tomorrow, after getting approval from doctor. Have any of you had these same or similar problems with Esbriet?

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Replies to "Hubby's in his 3rd week with Pirfenidone now, and the increase to 3 pills 3 times..."

Hubby called pulmonologist, but so far no response. The good news is that cutting back to the previous 2 pills 3 times a day helped. Today, at least. No stomach problems, and less runny nose side effects. What do you all do for runny nose??

Lots of sneezing, too. Wouldn’t you know it — doctor is out today. Supposed to call tomorrow. Meanwhile, second day of previous six pills a day dosage is still working fairly well. Is it possible that Hubbs will never be able to go up to the maintenance nine doses without experiencing extreme side effects? I mean, you can’t just go around with a bloody nose and/or runny nose and/or constant tummy tension and not wanting to eat — right?

How is your husband doing now? I will be starting one of the two anti-fibrotic drugs shortly, so I wonder what awaits me.
I don't know if any help, but I have had a problem of chronic runny nose for many years. Sometimes caused by certain medications and sometimes other things. My ENT recently gave me a saline nose rinse to try. It actually cleared out a lot of my nose and my nose is much drier now. It is sold off-the-shelf at drugstore so one does not need a prescription.

Thanks for your reply. I know Ayr brand and will get some gel to keep on hand.