Apalutamide (Erleada) for a year but PSA is now rising

Did you have distant mets when you started taking Apalutimide? Also, had you been on any type of ADT for an extended time before starting Apa?

I was on Erleada and ADT 6 months prior to and post RP and it has worked. I am 17 months with no med . If I were you I would talk with my urologist about ADT & Erleada and chemo and try to knock this cancer down. Good Luck

I had Stage 4 metatasasized to bones...Put me on Apalutamide and Erleada...PSA was going down, but now at 6 months , it is going up...
See the Urologist in 2 weeks..
Just wondering if this is normal to go up...It was at 2.4 in December last year and now going up every month..

I was on Xtandi for a year then PSA started doubling as it stops working

They were going to put me on chemo but since only in bone I got approved fro Radium 223 or Xofigio google that Injection every 4 weeks for 6 months
Only for bone mets Lu 177 for all cancers
They added Xgeva every 12 weeks I also take calcium 600 mg dailu with D and K
Zolodex every 12 weeks

So far (2 1/2 years) on ADT and Erleada (Apalutamide), my PSA has remained undetectable with the ultra-sensitive test, but I know that can change at any time. I have stage 4 PC with one bone metastasis, and have had two rounds of SBRT radiation (one to the metastasis site and one to the prostate itself). No chemo yet.

Hi Cal77, I thought that Apautamide and Erleada are the same medication. I was on Erleada and Orgovyx for 6 months, I had radiation at the 3 month point to a single metastasis (Lymph node in my chest). PSA was 13.46 before those treatments [RRP 24 months prior followed 6 months later by 34 rounds of salvage radiation to the prostate bed]. Three months into the latest treatment PSA was undetectable at 0.01 at 6 months on Orgovyx and Erleada PSA was still at 0.01 Three months after stopping both drugs PSA was 0.02 one month later up to 0.08, at now 6 months after stopping, PSA at 1.02 But the good news in all of that is all of my scans were stable, PSMA/PET scan, CT scan and Bone scan all we "stable". More treatments soon to come...
So to answer your question; no, I don't think that it is normal for your PSA to go up while you are on ADT. I also don't think that it is normal for your PSA to start climbing weeks after stopping ADT. Do you have an Oncologist as well as a Urologist? You may want to consider adding an Oncologist to your team if you do not have one yet. Neither my PPC nor Urologist recommended that I get a Oncologist. But I decided myself to find the best one I could in the area. Then asked my Primary Care Physician to give me a referral to the one I chose, which he did.
I think that everyone's situation is unique with this disease. But there comes a time that the expertise of a Clinical Oncologist is something to consider. I think it was the best thing I did and feel like I am getting better care and given more options than my former urologist was able to provide.
I wish you the very best.
Stay strong!

Look at Xtandi If you can get on Radium 223 or Xofigio for bone mets I am on 4th injection 79 and feel great

Something like that is the plan if/when there's any sign of progression. Right now, there's no indication that cancer is active anywhere in my body (though I know there are probably dormant cells hiding out somewhere).