Hi Cal77, I thought that Apautamide and Erleada are the same medication. I was on Erleada and Orgovyx for 6 months, I had radiation at the 3 month point to a single metastasis (Lymph node in my chest). PSA was 13.46 before those treatments [RRP 24 months prior followed 6 months later by 34 rounds of salvage radiation to the prostate bed]. Three months into the latest treatment PSA was undetectable at 0.01 at 6 months on Orgovyx and Erleada PSA was still at 0.01 Three months after stopping both drugs PSA was 0.02 one month later up to 0.08, at now 6 months after stopping, PSA at 1.02 But the good news in all of that is all of my scans were stable, PSMA/PET scan, CT scan and Bone scan all we "stable". More treatments soon to come...
So to answer your question; no, I don't think that it is normal for your PSA to go up while you are on ADT. I also don't think that it is normal for your PSA to start climbing weeks after stopping ADT. Do you have an Oncologist as well as a Urologist? You may want to consider adding an Oncologist to your team if you do not have one yet. Neither my PPC nor Urologist recommended that I get a Oncologist. But I decided myself to find the best one I could in the area. Then asked my Primary Care Physician to give me a referral to the one I chose, which he did.
I think that everyone's situation is unique with this disease. But there comes a time that the expertise of a Clinical Oncologist is something to consider. I think it was the best thing I did and feel like I am getting better care and given more options than my former urologist was able to provide.
I wish you the very best.
Stay strong!