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← Return to Orgovyx and Zytiga combined
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I’m checking in to see how you’re doing. How is your PSA?
My doctor wants to put me on Lupron and Zytiga. I’m asking him if we can substitute Orogovyx for Lipton for better testosterone recovery after 2ys and treatment ends. He is being cautious as they are no big studies on the efficacy of the combo.
Replies to "I’m checking in to see how you’re doing. How is your PSA? My doctor wants to..."
Same problem they don t trust anything that doesn’t have 5yr or longer studies. Orgovyx was only fda approved Jan 22. Long studies don’t exist yet . I’m on orgovyx/Zytiga only side effects fatigue and sweat a bit more. Orgovyx took my psa to undectable in 3wks still umdectable@months. Cautionary tale xytiga only seems to exist as generic abiriteroneacetate. Use 250x4 vs 50mgx2 huge ripoff in pricing on 500mg
I'm not sure if your onco is saying there are no studies on Orgovyx+abiraterone, or Lupron+abiraterone, but it should not matter. All of these patients being put on ADT + abiraterone/Zytiga with high risk localized or locally advanced disease are doing so based on the STAMPEDE trial that has been ongoing in the UK and Switzerland. One of the many trials included under STAMPEDE was for patients with high risk, non-metastatic disease. It did include patients with locally advanced disease , i.e., pelvic nodes. The latest reporting I saw was at 108 months from start of treatment PCa-specific survival was 85-ish% for the arm in which patients took abiraterone in addition to ADT and high 60's% in the arm with ADT only. That is a huge benefit and is what caused the standards bodies to designate this combination therapy for high risk, non-metastatic patients as Standard of Care. There was no distinction made by the type of ADT used in both arms, so Lupron versus Orgovyx should be a non-issue.
So I would press your doctor to show you proof there is no evidence of that combination being used. It has been Standard of Care for some time now. Mention the STAMPEDE trial.
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Not sure if you’re asking me, but my docs have had me on both Ziga and Orgovyx since I had my proton therapy radiation last August. I am supposed to stay on both meds for two years. The orgovyx has been easy for me to tolerate, and I have had no side effects, except for the usual hot flashes. from my friends experiences with Lupron, I believe the Orgovyx is a more tolerable treatment. And, as you say, I believe that it’s a faster recuperation when we stop the Orgovyx.
I do have a noticeable drop in energy levels, and a little frustrated that I have to stay on these meds for two years. Since my proton therapy I’ve had two PSA tests both are less than 0.01.