Breast cancer patient also with osteoporosis: AI, Prolia and Reclast

At least the restricted plasma level of the bone-derived protein, SOST, is correlated with reduced brain Aβ load in a cognitively unimpaired older adults. https://www.ncbi.nlm.nih.gov/pmc/issues/427415/
My concern is cardiac valves.
I think the reluctance to prescribe is entirely the evidence from rats predisposed to cancer. The registery that allowed the elimination of the black box would have to have been skewed, who would prescribe and who would take the risk. Mostly white women of our age. But no mechanism of action has been proposed.
The internet is rife with the now retracted warnings. I wish at least the universities would delete the disproven information from their sites.
I spoke with an endocrinologist last week who was not aware of the change for Forteo and skeptical of its existence.
I would so love to hear your dreams.

"Atypical Femoral Fractures: Atypical low-energy or low trauma fractures of the femoral shaft have been reported in patients receiving EVENITY®. Causality has not been established as these fractures also occur in osteoporotic patients who have not been treated.

During EVENITY® treatment, patients should be advised to report new or unusual thigh, hip, or groin pain. Any patient who presents with thigh or groin pain should be evaluated to rule out an incomplete femur fracture. Interruption of EVENITY® therapy should be considered based on benefit-risk assessment."
I'm pretty sure you've alread seen this.

I'm on Prolia so I can't answer your question (although next month I plan on asking my oncologist for an alternative). What I find interesting is that the oncologist won't treat for osteoporosis. My case is somewhat different in that I'm at the osteopenia stage, and my primary care doc won't treat for that because Medicare doesn't cover it unless you're on AI's. I'm on my 4th oncologist (long stories there), but all 4 just assumed treating my osteopenia. It's not the Healthcare systems because they're in 3 different systems. Weird.

@windyshores I would like to know how you managed your osteoporosis while on Letrozole?

Hi there. Just wondering how you are doing? Did you take Prolia? I was thinking of taking HRT for my menopause symptoms and my osteoporosis, but I have a high risk of breast cancer....If I develop breast cancer I imagine I'll end up in the same boat as you. Did you have a hard time transitioning off of HRT? Did you talk to your doctor about transitioning off of an AI and trying Tamoxifen instead? I hope you are doing well and continuing to live your best life!

Hi there
I’m 2 yrs into anastrazole for stage 1 bc. Zometa was part
Of my treatment and I have osteopenia. I did 3 infusions
Every 6 mos. They are not easy, but I did request extra fluid and took Tylenol so it was bearable. I work with weights 3x a week and so far I’m doing well. I’d love to try hrt but oncologist isn’t for it yet.

@sherrilei I am not understanding why you are thinking you should take HRT if you have estrogen positive breast cancer. I understand they have said it doesn’t increase your risk but if you already have breast cancer that is driven by estrogen, I would think HRT would be off the table.
I am curious if your doctor thought you could avoid the risk of recurrence and still take it?

According to Dr Avrum Bluming, author of Estrogen
Matters, estrogen isn’t the reason for the cancer.
It’s the receptor. Also anastrazole removes estrogen which for a postmenopausal woman is valuable for your heart and bones. So occasionally my oncologist is permitting me to have organic soy milk. Estrogen is the glue that keeps us together. Check out the book, he gives a better explanation. Food for thought, always checking new data too.

@sherrilei I spoke with nutritionist who works with breast cancer patients and she said it is fine to eat soy - tofu and other products. It isn’t going to interfere with treatment or being on an ai med. So I am surprised the oncologist said you could have soy milk only once in a while?

@sherrilei Did you have osteoporosis before going on an AI? I have osteoporosis now and I'm trying HRT for my osteoporosis and menopause symptoms. I'm already at a 20% risk of breast cancer and I'm told a 4 year course of HRT won't increase my risk. I'm just wondering what women with osteoporosis do if they end up developing estrogen + breast cancer. The AI's really weaken your bones.