@gently I worry that the effects of sclerostin suppression are not adequately studied. Most studies are on cardiovascular effects and those studies showed no difference in risk between Evenity and placebo, and small difference (but significant) between Evenity and alendronate (which might be because alendronate has a positive effect).

But sclerositin is throughout the body, including central nervous system, joints/cartilage....I am having long complicated weird dreams that have no connection to daytime concerns. In some ways that concerns me more than joint pain.

For breast cancer, I was told Reclast , and my cousin is on Zometa- both zoledronic acid. I wonder if doctors are hesitant to prescribe bone builders like Forteo, Tymlos, Evenity because they can't be given when metastasis is possible. Maybe in early cancer this is still an issue if/when cells are still wandering around-???