My BMB went extremely well. I was given an IV tranquilizer along with the pain meds which helped tremendously. For me, the hardest part of the procedure was getting comfortable enough laying on my stomach so that I would not need to squirm during the procedure. I was very well-cared for by the NPs who handled the procedure - all female, I might add :-). It was quick, easy, and while I did have some soreness and swelling at the biopsy site, it was not a big deal. The wait for the results was the hardest part! Mine confirmed Essential Thrombocytosis - no other indications of more serious issues.