1. < MAC & Bronchiectasis

What is the purpose of saline

Posted by lorrainewenn @lorrainewenn, Apr 1 8:21pm

What is the purpose of Saline for MAC management? I do ACT twice a day with 7% saline. I typically cough up a lot of mucus. Still not on antibiotics, in the watchful waiting phase.

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@ling | @wangling | Apr 3 10:55am

NYU Langone health clinical trial status currently is still open. Anyone is interested. It seems that European countries have done some research in this area, including it in the treatment guideline.
The trial ---- Hypertonic Saline for Treatment of Pulmonary Mycobacterium Avium Complex (MAC) Diseaserecruitment
https://clinicaltrials.med.nyu.edu/clinicaltrial/1804/hypertonic-saline-treatment-pulmonary/?section=elg
Ling

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sadair20 | @sadair20 | Apr 3 1:37pm
In reply to @scoop "For general pulmonologists who do not specialize in bronchiectasis with or without MAC, this seems a..." + (show)
@scoop

For general pulmonologists who do not specialize in bronchiectasis with or without MAC, this seems a typical response that you "don't need 7%". Same happened with me. Finally, I convinced them to let me give 7% a trial. It made a big difference in clearance for me.

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Thanks, I do think this is the case with my pulmonologist but he does seem quite knowledgable about Bronchiectasis and MAC. I sent him the study and asked for him to reconsider.

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happyhealthyme | @happyhealthyme | Apr 4 9:46am
In reply to @lorrainewenn "This is exactly what I was looking for! I’m a science nerd so I will study..." + (show)
@lorrainewenn

This is exactly what I was looking for! I’m a science nerd so I will study this and see if this article provides guidance on how long it might take for 7% saline, twice per day, to reduce MAC avium concentration in the lungs.

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While you're at it -- I refer to your planned study as to the effectiveness of 7% saline twice per day, please also let us know the once-per-day effectiveness.

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suzanne11 | @suzanne11 | Apr 9 12:52am
In reply to @equanimous "From the research I have read, saline provides an inhospitable environment for MAC bacteria which helps..." + (show)
@equanimous

From the research I have read, saline provides an inhospitable environment for MAC bacteria which helps slow down its growth. It has additional benefits but, for me, that is the most important attribute since I am not choosing to take the Big 3 antibiotics.

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How long have been diagnosed with Mac?

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1 reply
AZ | @equanimous | Apr 9 12:59am
In reply to @suzanne11 "How long have been diagnosed with Mac?" + (show)
@suzanne11

How long have been diagnosed with Mac?

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Since 2019.

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suzanne11 | @suzanne11 | Apr 9 1:06am

No antibiotics?

I have been diagnosed since 12/2022. I have not taking antibiotics yet, but every month I get a really bad infection. I don't cough, but I have a lot of green sputum. I feel so sick. 🙁

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jassa | @jassa | Apr 11 12:58pm
In reply to @sueinmn "@sadair20 & @lorrainewenn - Here is the link to the most used study of hypertonic saline..." + (show)
@sueinmn

@sadair20 & @lorrainewenn - Here is the link to the most used study of hypertonic saline and Mycobacteria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850692/pdf/13104_2016_Article_2054.pdf
Feel free to read the entire discussion, but pay special attention to Table 2 on page 4. They grew various strains on plates in the lab, with varying concentrations of saline on the medium. By the time they reached 7% almost none of the strains was able to reproduce. Table 3 on page 5 also shows the sizes of the colonies that were able to grow at various concentrations - they decreased significantly at 5% saline and above.

Sue

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Thanks for this study. It confirms my gut feeling about salt therapy. I used to go to a salt therapy clinic, where you would sit in a room for a half hour and breathe the salt vapors in the air. I wasn't sure if it was working and I stopped. Now I wish I continued.

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