Beginning at a dose of 1.5 mg I had heart palpitations. I stayed off it for a week and tried again. I started again. I was OK. I went up a week later to 3.0. Had more problems. I was put back to 1.5. After a week I went up to 2.0. This time I stayed at that level for 2 weeks. Then I went to 2.5 for 2 weeks. Next came 3.0 for 2 weeks. When I went up to 3.5 I had some problems and went back to 3.0 for another week. Stayed at 3.5 for 3 weeks. Just a week ago I went to 4.0. Will stay on that for another 2 weeks. The final dose is 4.5mg. I have some pain relief but I read it can take up to 9 months for the full effect to take place. The pain I have can be relieved by pain management but it is a Workers Comp case and they just keep denying procedures delaying pain relief right now for cervical problems. Sleeping causes neck and head pain. I especially do not like headaches, not that I like any pain but I have a lower tolerance for headaches. My faith sustains and encourages me to carry on looking forward to pain relief. I believe in Jesus's healing and have had such in different times in my 80 years.