Thanks for your reply! When you're worrying about these setbacks, it's comforting to speak with someone. Transplant team wrote for the metoclopromide. They did this no doubt because anything ingested, including immune suppressing meds, seemed to be 'sitting' where the esophagus enters the stomach. That's how it felt to her. Before increasing frequency of Zofran dosing, some of the suppressant drugs may have been lost. So it's a tough call. I'm sure the team is familiar with tardive dyskinesia. Now that she has been able to keep down meds and some food for a couple of days, we will suggest to the team that we try to back off the Reglan. I don't know what might better replace Reglan. She's already taking Zofran, but that doesn't do much for upper GI motility. If we wanted to be off Reglan, the only thing I can think of is IV meds, fluids, and nutrition. Hopefully we're to the point now where food and meds can reliable be absorbed......