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Thoughts on Prolia?

Osteoporosis & Bone Health | Last Active: Jun 7 1:45pm | Replies (45)

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@windyshores

@sheezit maybe you could get a copy of Keith McCormick's book "Great Bones" or watch some YouTube videos (I like Dr. Ben Leder's video "Combinations and Sequencing Approaches to Osteoporosis."

Maybe it helps to know there are two main groups of medications: bone builders and anti-resorptives (which affect turnover).

1) Bone builders: Tymlos, Forteo or the first 6 months of Evenity

2) Anti-resorptives: bisphosphonates alendronate (Fosamax), Reclast; or Prolia; or second 6 months of Evenity

The sequence of meds is important and despite insurance wanting us to start with anti-resorptives, it is much better to do bone builders first. Bone builders should be followed up with Reclast or alendronate to "lock in" gains and at some point a drug holiday may be possible.

Prolia works really well but patients can end up even in worse shape after stopping, unless Reclast is able to prevent the rebound. If I were in my 80's I would consider it and just never stop, but otherwise, I would avoid it based on my doctors' advice.

Hope that helps! A good endocrinologist is very helpful with all this but should also allow you to make choices.

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Replies to "@sheezit maybe you could get a copy of Keith McCormick's book "Great Bones" or watch some..."

I tolerated alendronate very well for 5 years. Now on shots 7 of Evenity. Any reason why I shouldn't go back on alendronate after evenity I stead of prolia or other thoughts.