Hello @jrc3vette, Welcome to Connect. I'm sorry to hear your wife has not found much help for the neuropathy pain. I only have the numbness and some tingling with my neuropathy but I also take supplements since being diagnosed 2016. I shared my neuropathy journey in another discussion here - https://connect.mayoclinic.org/comment/310341/.

The Foundation for Peripheral Neuropathy has a list of supplements that have shown to help with neuropathy symptoms in their list of Complementary and Alternative Treatments here - https://www.foundationforpn.org/wp-content/uploads/2020/08/Complementary-and-Alternative-Treatments-Revised-2020-final.-1.pdf.

I do take the supplements you listed along with others as part of the supplements I have been taking since 2016. There is a link to the list that includes links to the research for the supplements that I shared in another discussion here - https://connect.mayoclinic.org/comment/957496/.

Are you able to share more about your wife's diagnosis and her neuropathy symptoms?

Hello, jrc3vette (@jrc3vette)

And welcome!

I wasn't able to have a substantive conversation with a doctor about supplements until I inquired about and was sent to see a physiatrist, the sort of neurologist (and you may know this; I didn't at the time) who emphasizes physical rehabilitation to counter nerve damage. He put me on a "medical food" known as EB-N5, but that was what he had hoped might help with my particular form of neuropathy: idiopathic sensory-dominant polyneuropathy.

Symptomatic of my neuropathy is no pain; my challenges are balance and gait. Although I don't it for a fact, it's possible that EB-N5 is hoped to help those where pain is not their overriding concern. I thought I'd tell you of my experience chiefly to say that, for me, it took finally finding a doctor who was conversant in supplements and nutrition before I'd been given anything to try.

I wish you and your wife well and help with her most immediate needs that's not too long in coming.

Cheers!
Ray (@ray666)

This may be preaching to the choir, but I thought of an analogy that fits my determination to find a more suitable solution for my wife's Neuropathy. I thought I would share it in the hope that it inspires others.

A faucet is slowly leaking. Then, the drain becomes clogged. Once the sink is full, water starts leaking all over the counter. Even if you find an effective way of mopping up the water that is all over the counter, the faucet is still leaking and the drain is still clogged. Water will continue to go all over the counter unless the faucet is fixed or the drain is unclogged. This endless cycle is like a pain management centric treatment.

I strongly believe the medical industry is heavily influenced by the pharmaceutical industry. There is less profit in fixing that leaking faucet or unclogging that drain than there is in simply providing aid to help with mopping up the water indefinitely.