I have been on more anti-depressants than I can remember, but among those I've had prescribed to me, in addition to Seroquel, are: Celexa, Lexapro, Wellbutrin, Prozac, Cymbalta. It was Cymbalta that triggered the mania which got my diagnosis modified from depression to bipolar. After the new diagnosis I was on a mood stabilizer, Abilify, which worked, but had akathesia as a side effect, which was miserable. Beta blockers helped alleviate the akathesia, but it was still a deal breaker. By far my worst experience was with Cymbalta. Much of the experience with Cymbalta I cannot remember, I think I have blocked off that memory - too difficult to relive. I also developed tinnitus when I abruptly stopped Cymbalta, and still have it years later.