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Kappa light chain is elevated: Anyone dealing with this?

Blood Cancers & Disorders | Last Active: Mar 23 6:45pm | Replies (44)
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@connectingdots

My thoughts are that I may not actually have MGUS as my kappa lambda ratio is quite low 3.36 though still outside the normal range. There are several journal articles about reactions to the Covid vaccine resulting in chilblain like lesions. I don’t know the quality of these journals. I am wondering if I may be having a mild reaction to the vaccine that’s causing my immune system to respond a bit.

The journal articles are based generally on a very few instances. I’m still not allowed to send any Internet addresses.

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Replies to "My thoughts are that I may not actually have MGUS as my kappa lambda ratio is..."
Colleen Young, Connect Director | @colleenyoung | Mar 23 3:00pm

@connectingdots, I noticed that you wished to post URLs to several journal articles with your post. You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe.

Allow me to post them for you, including the titles of the papers:
- SARS-CoV-2 Vaccination and Chilblain-like Lesions: What Do We Know so Far? (2022) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681186/
- Free Light Chains κ and λ as New Biomarkers of Selected Diseases (2023) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253807/

- Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as Mechanism (2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500133/

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