From my own personal one year on both Anastrozole and Tamoxifen I would say that a reasonable dose of Tamoxifen would be far easier to tolerate than any of the A.I. drugs. If my cancer were a higher stage and grade than it was at the outset, I would have tried to tolerate Tamoxifen longer, but I would probably reduce the dosage or do it every other day. My feeling now is that the cure has been worse than the disease and, while I am as apprehensive as every single cancer survivor in America, I've got to quit doing the very thing that makes me feel that life is almost not worth living. I still would like the ki67 test, to see how slow or fast-growing the tumor was, which would give me some peace of mind, but my current oncologist (Tx) said that the results of the oncotype he fought to get for me gave him more information of that sort then the ki67 test would have. I recently sat through a presentation about a "natural" item that is supposed to help suppress cancer cells and will give that a try, but I really feel that research involving older women is long overdue and that the "one size fits all" approach towards medication is totally illogical.