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Anyone take new drug Camzyos (mavacamten) for HCM?

Hypertrophic Cardiomyopathy (HCM) | Last Active: 1 hour ago | Replies (705)
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@deanna529

Thank you for your concern.
I have been off of Camzyos for a long time already. I am now in a clinical trial for Aficamten. Week 16. I always am asked what new meds I am on by my team. I reiterate that they never questioned me about OTC meds. ( like allergy, Tylenol.) Common sense is my best friend. If I am on a new Rx, then of course I run it by them.
Good luck to you.

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Replies to "Thank you for your concern. I have been off of Camzyos for a long time already...."
manuelpo | @manuelpo | Mar 23 9:26am

Hi @deanna529
Thank you for the valuable information about Aficamten. Week 16. I wonder if that medication (Aficamten) at this clinical trial week 16 is helping you or not to safely lower the left ventricular outflow tract (LVOT).
What is stated in a publication is that:
"aficamten has a shorter human half-life (t1/2) and fewer drug-drug interactions, making it a preferable treatment option. This review evaluates the long-term clinical value and safety of aficamten in patients with obstructive HCM based on available data from completed and ongoing clinical trials. Additionally, the molecular basis of sarcomere-targeted therapy in reducing LVOT gradients is explored, and its potential in managing obstructive HCM is discussed". Please see this statement here: https://pubmed.ncbi.nlm.nih.gov/37526885/

I wonder if the statement published above applies to you or not since every patient result is different and if this could be a good option for future HCOM patients medical treatments.

Thank you!

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