@przngard Hello Wade. I found a website where you can search between locations to find transportation. There is Amtrak service from Chicago across Wisconsin, and then a bus route from Winona, Minnesota to Mayo. It looks like you can take Amtrak from Macomb, IL east to Chicago. That's about twice as long as if you could just drive from Beardstown because you are already pretty far west, and Mayo Rochester is to the north of where you are.

Here is the link. You can do your own search there. Patients also fly into the Rochester airport.
https://www.rome2rio.com/map/Beardstown/Mayo-Clinic#r/Taxi-train-bus
You may also want to contact the free Concierge service at Mayo to see if they can advise other travel options.

Five Ways to Contact Mayo Concierge Services
Phone: 507-538-8438
Live Chat: https://www.mayoclinic.org/patient-visitor-guide
Email: concierge@mayo.edu
Web form: https://www.mayoclinic.org/patient-visitor-guide/minnesota/becoming-a-patient/concierge-travel-services