So sorry your mom is experiencing such negative side effects from hydrea. Question: What is your mom’s platelet count? I ask because I was diagnosed with E.T. in 2021 with platelet count in mid 500s. I chose not to take Hydrea and get blood tests every 3 months. I also take a baby aspirin every evening. My platelets have stayed in the mid 500s and I feel fine. I am 82. I mention this since the doctor said the alternative for your mom is to do nothing. It sounds as though your mom is emotionally and physically wrought with the side effects of Hydrea. Depending on her platelet count, perhaps doing nothing may be an alternate plan. I do not want to sway you/her in any way. Just want you to know this is an option you may want to discuss with her doctor. Wishing your mom the very best outcome.