For me, the brain fog and lethargy were worse before HU, and ocular migraines went away after I started HU. But I have heard many fellow patients say the trouble started with HU, so I don't doubt it. I am also CALR+, and I wonder if that makes a difference. I wish they would study this.

Brain fog is common with infused chemo for acute cancers. So I wonder if HU, mild as it is, has that effect for some. Again, would be good to know if it's disease or meds.

My doc told me that the lethargy/fatigue are common symptoms of any blood cancer, along with the night sweats. I keep my bedroom cold and exercise to fight the lethargy. Helps.