The article below states that MGUS may be associated with bone loss and debilitating skeletal complications. I had osteopenia before I was diagnosed with MGUS. Did the MGUS cause the osteopenia? I don’t know.

The article recommends that the status of your bones be evaluated. This can be done rather crudely with a skeletal x-ray survey, more precisely with a PET/CT scan and MRI for spine and pelvis. Please ask your doctors to evaluate your bones. If your bones are damaged, there are things that can be done to strengthen and repair them. This will eliminate your pain.

“Recent studies have suggested the association of MGUS with enhanced bone loss and debilitating skeletal complications, particularly vertebral compression fractures (VCFs) often leading to back pain. Early identification of MGUS and evaluation of bone status will facilitate prophylactic treatment with bisphosphonates to increase bone density and likely reduce the risk of fractures as well as identify patients with VCFs who might benefit from early surgical intervention. With proper diagnostic and treatment strategies, these patients will experience improved outcomes and quality of life.”