https://www.ncbi.nim.nih.gov/pmc/articled/PMC7862223/
2021 article: Menaquinone 4 increases plasma lipid levels in hyoetcholesterolemic mice.
Study by: Weisell, Ruotsalsinen, et al

FYI, I am not a mouse and mine increased substantially. Three months after stopping, it went back down. Hoping estrogen lowers it further.

I guess my caution would be that even supplements have effects and side effects and everyone is different. I just happened to stumble on this, knowing it was the only change I had made. Another good reason to add things one at a time when possible,