Plasma Rich Platelet ( PRP) - Looking for treatment feedback.

Posted by shielashepperd @shielashepperd, Mar 18 9:27am

I am one year post treatment for Hypopharyngeal cancer. I am experiencing moderate Dysphonia. My vocal chords took a beating. Doctor suggested Plasma Rich Platelet treatment (PRP). I have not decided because I feel like it might be a boost to the bad cells (cancer). So, I wanted to check if it was worth it or if anyone has any research on this topic.

Published data is very limited weather it boosts cancer cells.

Thank you,

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I am curious why it would boost cancer cells. I have been told that it tightens things up by causing inflammation. My daughter has had it twice on joints and it was miraculous, but I don't know anything about your situation.

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I believe you just hit it on the nail of my concerns: Inflammation. It's perfect for the setting for your daughters case because she wants angiogenesis to the tissues for healing. But my question is for someone that has researched this, if it does the same to cancer cells?

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@shielashepperd

I believe you just hit it on the nail of my concerns: Inflammation. It's perfect for the setting for your daughters case because she wants angiogenesis to the tissues for healing. But my question is for someone that has researched this, if it does the same to cancer cells?

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It worked overnight for my daughter. They take blood, concentrate it and inject it back in.

I have also had cancer. I have not read anything about PRP and cancer. Can you share? I will look into it since I am considering it as well.

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I have a fabulous doctor part of a cutting edge medical team that only work with Head and Neck cancers so I don't think he would suggest PRP if it could potentially ignite recurrence. On the other hand, it sounds like putting Miracle grow in the garden...weeds/cancer would benefit as well. So I know nothing and was hoping for answers.

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It seems they are investigating this issue, and PRP may even be used in cancer treatment, but with caveats. It may be hard to get a definite answer. Personally, I would do it since benefit might exceed any risk. Like so many of us, it is unlikely you will get certainty. If you had metastases risk might be greater then benefit. I am sure you have seen these:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113436/#:~:text=PRP%20may%20have%20opposite%20effect%20on%20tumor%20growth,released%20by%20PRP%20can%20contribute%20to%20tumor%20progression.
"Although PRP use in cancer patients is a promising approach that needs to be further explored, caution must be taken since PRP may have opposite effects on tumor growth and metastasis. growth factors released by PRP can contribute to tumor progression."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470624/
https://pubmed.ncbi.nlm.nih.gov/32258495/

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Interesting topic. Many of us have had a change in voice after radiation to the neck and some just from surgeries and/or Chemo. My feeling is this may be a can of worms you may not want to get into and accept the fact that your voice is no longer the same. Again, just an opinion. Sometimes we go down a rabbit hole trying to bring ourselves back to the way things used to be. But with every cure there seems to be a side effect. It will be interesting to see where this goes.

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@hrhwilliam

Interesting topic. Many of us have had a change in voice after radiation to the neck and some just from surgeries and/or Chemo. My feeling is this may be a can of worms you may not want to get into and accept the fact that your voice is no longer the same. Again, just an opinion. Sometimes we go down a rabbit hole trying to bring ourselves back to the way things used to be. But with every cure there seems to be a side effect. It will be interesting to see where this goes.

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PRP is so quick though. I cannot find info on lasting effects that are relevant to cancer growth. The benefit happens in a day or two for some. Is it possible to wait or contact researchers via your doctors?

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Thank you for your responses. I feel the same as both of you. I will continue to wait until I know more info. I suppose it would be hard to find out if it doesn't promote cancer growth. Thank you again. I"'ll stay tuned.

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My approach is to take meds with risk to metastatic cancer, as long as my primary cancer has not spread as yet. In my case, bone-growing meds. Not sure how that applies to PRP. The daughter who has benefited from PRP has three autoimmune disorders and suffers inflammation anyway. For her, the issue is that the joints "slip" (sublux) which results in inflammation. In the long run, therefore, PRP eliminated subluxation and reduced inflammation.

I found this online (rosm.org)

PRP can help promote healing and reduce inflammation12. Platelets contain growth factors that help promote healing and tissue regeneration12. When injected into the body, PRP can help stimulate the body’s natural healing processes and reduce inflammation1. However, PRP will initially cause acute inflammation to heal the problem, which could hurt for a few days3. PRP injections are not recommended in individuals with bleeding disorders, those taking anti-coagulation medications, or those who have cancer, active infections, or are pregnant4. Doctors may use PRP to reduce inflammation in people with OA and rheumatoid arthritis5.

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