Evenity cardiac and stroke side effects update

This is very interesting. I am 67. My choices were Forteo or Evenity. Since I have had breast cancer twice, my oncologist and endochronologist chose Evenity. Dr McCormick wanted me to do Forteo. But I don't want any chance of bone cancer. I just had a nuclear stress test and blood work prior to Evenity, which delayed me three months. My CT calcium score is 0. I just got cleared for the injections and will start Tuesday! My blood calcium was checked and needs to be checked prior to every injection.

It is all very nerve-racking and confusing, but mostly I am excited to be able to start it.

Best wishes to you.

It helped me to read the actual studies. Cardiovascular effects were the same in a study comparing Evenity to placebo. They were slightly worse with Evenity than alendronate but the report hypothesized that that could be because alendronate is slightly protective.

Evenity inhibits sclerostin and sclerostin has effects throughout the body, including blood vessels. I have read that more studies are needed on other aspects of sclerostin function that might be affected and there was too much focus on cardiovascular effects. I am more concerned about other effects, such as a possible reduction in acquired immunity (B cells produced in bone marrow). Not much is known as yet.

Most people seems to be doing fine on Evenity and it seems as if post- FDA approval reporting is not revealing a lot of new problems. (I am one of the few I know who is actually having side effects...)

The bone cancer warning has been lifted for Forteo. Not a single human has developed bone cancer on Forteo. The rats were given very large doses in the studies.

I saw some concern about cancer for Evenity somewhere too. It would take some digging to find but I'll try. I believe it was theoretical and not from studies with rats.

I have had breast cancer (once) and was okay with either of these, or Tymlos. If I had any metastasis, I would not take either Forteo or Evenity.

It helped me to read the actual studies. Cardiovascular effects were the same in a study comparing Evenity to placebo. They were slightly worse with Evenity than alendronate but the report hypothesized that that could be because alendronate is slightly protective.

Evenity inhibits sclerostin and sclerostin has effects throughout the body, including blood vessels. I have read that more studies are needed on other aspects of sclerostin function that might be affected and there was too much focus on cardiovascular effects. I am more concerned about other effects, such as a possible reduction in acquired immunity (B cells produced in bone marrow). Not much is known as yet.

Most people seems to be doing fine on Evenity and it seems as if post- FDA approval reporting is not revealing a lot of new problems. (I am one of the few I know who is actually having side effects...)

I think that of the two studies that have been done, FRAME and ARCH, one showed a hightened risk of major acute cardiovascular events, and the other did not. The one that involved older subjects it the one that showed a risk.

I am having a lot of neurological side effects. I want to emphasize this is unusual. Numbness, pins and needles, pain, dreams, fatigue and most of all, burning sensations all over and especially chest. I decided to post this in case anyone else has this. I had two shots then one shot, and last time was one shot. I would say that the symptoms are progressive. So if anyone does have these- unlikely as it is- don't think that they will improve with continued exposure. Continued exposure at low dose followed by gradual increases, helped me with Tymlos but not Evenity.