Hi,
I have posted earlier about my situation (now age 79, started Venetoclax and Decitabine 2 years ago at Mayo Jacksonville, still in remission). To answer your question, I did start with this drug combo. The main side effect (beyond fatigue that is manageable with naps!) has been low neutrophil counts between treatment cycles. That means I am sometimes immunocompromised, limiting the time I can go to indoor, people-intensive places. To manage that side effect (which I believe is fairly common), my doctors have gradually reduced the number of days I take Venetoclax (originally 21 days, now 7) and the length of time between cycles (originally 4 weeks, now 5 weeks which means that about 3 weeks out of 5 I am immunocompromised.)

I hope you are able to ask alot of questions of your hematologist. It takes awhile to wrap your head and heart about the nature of AML and treatment options. I wish both of you good luck on this journey.
Linda