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Mayblin here is a clinical trial that is looking at shorter courses of Evenity. It appears to have started in late 2023. The results won't be in until 2026 unfortunately (if it stays on schedule).
"The study will investigate if it is possible to maximize the effect of romosozumab by giving it in 2 periods of 6 months interrupted by zoledronate for 12 months compared to romosozumab for 12 months uninterrupted followed by zoledronate for 12 months. The investigators will also evaluate if 6 months of romosozumab followed by 18 months of zoledronate is non-inferior to the standard regimen of romosozumab for 12 months followed by zoledronate for 12 months."
Links (both are about the same study):
https://ctv.veeva.com/study/the-optimised-use-of-romozosumab-study
https://classic.clinicaltrials.gov/ct2/show/NCT06059222
Replies to "Mayblin here is a clinical trial that is looking at shorter courses of Evenity. It appears..."
@awfultruth thank you so much for this powerful search result! Can't wait till the results come out. I'm curious about the zolendronate choice. In theory zolendronate is the strongest and longest acting of all bisphosphonates, how would it affect osteoanabolic effect? In theory it would dampen. Would a lower dosing or shortened treatment period (with lower dose) be better? Note that the study includes only patients with prior fracture within 3 years. Also, one of the labs for this study is ogtt. Does this imply glucose metabolism would be affected by the meds or would an imparied glucose metabolism influence the results?
Does anyone know how long does zolendronate stays in the body, or it's terminal half life?
How do you get this search results (for a clinical trial that's on going)? If you come across any on going clinical trials for extended treatment for forteo beyond 2 years or cyclic treatment with forteo, please share. I'm ready to volunteer.
Thanks a lot!
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@awfultruth looks like I am doing a 6 months Evenity, 12 months Reclast, 6 months either Reclast or Evenity trial myself!! Or maybe even shorter time on Evenity. I wish I was in the study! Thanks. I will copy this for my doc.