Issues with Metabolizing Antidepressants

Has anyone found that they now metabolize antidepressants differently? If so, have you found a way to explain this to a psychiatrist or other doctor?

Specifically, my psychiatrist decided I was on too many meds and has been tapering me off several that I was on before I got COVID and subsequently Long COVID, which from a depression standpoint has been so-so, but I found that I started having severe reactions to antidepressant withdrawal that I previously never had. For example, I went off Seroquel and I wound up not being able to walk straight, and then got a six-day long migraine. However, I started feeling noticeably better after that got out of my system, so I stayed off it. I’ve had similar reactions to stopping two others she wanted to stop, including SSRIs (which aren’t supposed to be as severe as SNRIs). I haven’t regained my appetite fully, but my energy and strength have gotten better. Prior to COVID, whenever I stopped a med or changed from one to another, I only felt off and had those weird brain zaps, but never the nausea, migraines, etc. I read a publication about a patient at UCLA that developed serotonin syndrome following a COVID infection although the patients meds didn’t change, but that patient was so sick that he had to go to the ER and I never got there.

Thoughts or similar experience?