It's been 8 days without Hydrea pill at all and knees are st hard to walk on without holding on to something or pain when walking. My news were perfectly normal and wonderful until I started chemo pill Hydrea twice a day. I see doctor today and hopefully chemo didn't cause damage to my knees. Still very tired also. I was a very vibrant 76er year old till all this happened. It's very disappointing. Thanks for input