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Brachioradial pruritus. (severe itching on forearms and neck, no rash).

Skin Health | Last Active: Mar 30 6:20pm | Replies (678)
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@tinalk

Have you ever done any genetic testing? Wondering about your low b12 and the possibility of MTHFS gene mutation (pretty common) which is linked to a whole slough of conditions.
I have had BRP for about 15 years now. I'm also chasing down some testing to see if I have the MTHFS gene mutation, which is linked to the laundry list of other issues I live with - but not (yet) to BRP.
One of the signs of MTHFS mutation is low b12.
Be interesting to see if anyone else has attempted to make this connection.

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Replies to "Have you ever done any genetic testing? Wondering about your low b12 and the possibility of..."
Lori, Volunteer Mentor | @loribmt | Mar 10 7:51am

Welcome to Connect, @tinalk. The MTHFR gene mutation may contribute to a variety of health conditions. Sounds like you’ve been doing your research to see if any of your symptoms might be related. I’m tossing in another article about MTHFR just to add to your information library:

MTHFR
https://www.medicalnewstoday.com/articles/326181

There are a few references in the forum from other members who also have the MTHFR mutation and mention low Vit B-12. These comments are scattered in various support groups but I thought you might find them helpful.
> @cll also has the MTHFR gene variant and experienced a deficiency in several B vitamins and Vit C. They share their experience in this post regarding:
GI disorders and internal shaking
https://connect.mayoclinic.org/comment/722029/
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@kefnb shares their experience and what has been helpful with MTHFR and a correlation between Vit B12 in this comment:
>Treatment for chronic Epstein-Barr virus (EBV)
https://connect.mayoclinic.org/comment/733044/

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@80rosy shares briefly their experience with MTHFR and low Vit B levels.
https://connect.mayoclinic.org/comment/287581/
~~~~~~~~~~~~~~~~~~~~~~~

There are a number of member comments mentioning MTHFR…too numerous to link here. However, if you type in
MTHFR in the top search bar, you’ll see many pages of references.

I hope you’ve been able to find relief for your BRP. Are there treatments for this?
Have you been able to have the genetic testing? What other symptoms are you experiencing?

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ilyne | @ilyne | Mar 30 6:20pm

Sorry I havent open much mail from this site. Just found your message. She has not been tested for low B12 and this MTHFS is new to us. Can you briefly explain it?

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