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M-Spike, High Kappa and Kappa/Lambda Ratio

Blood Cancers & Disorders | Last Active: May 7 11:35am | Replies (78)

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@aczatx47131

Dr. Urvi Shah at Memorial Sloan Kettering is studying how nutrition may slow the progression of MGUS (and maybe smoldering) to myeloma. She has lots of videos of her webinars on YouTube.

Eating a plant-based diet may help prevent MGUS turning into myeloma. Dr. Shah recommends eating tofu, tempeh and beans as the sources of protein rather than meat, chicken, eggs, etc.

Turmeric is a spice that kills myeloma cells in a Petri dish. Science has not determined the effect of turmeric on myeloma cancer cells in humans. I sprinkle one teaspoon or more on my food several times a day. I drink golden milk with turmeric and black pepper. Be sure to eat black pepper with turmeric to aid digestion. A plant-based oil is also recommended. I have a high-risk mutation, but my myeloma is not progressing as expected. I think it is the turmeric slowing the progression, but doctors don’t confirm this because of the lack of scientific evidence. Dr. Shah suggests supplements with curcumin, the active part of turmeric.

Dr. Shah has clinical trials about nutrition for newly diagnosed patients and patients with MGUS, I believe..

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There is a tiny percentage of curcumin in tumeric, and it is very poorly absorbed by the body; absorption is increased by the peperine in black pepper. The peperine can irritate the GI tract in some people (me). I have IgA kappa MGUS and take 1000 mg 2x/day of bioavailable curcumin capsules. The curcumin is modified slightly to increase absorption by the GI tract and retention in ones body (by attaching a lipid [fat] to the curcumin molecules, for example}. Research suggests curcumin is useful for moderating kappa levels, although studies and results are still limited. I'm good with being a lab rat. https://pubs.acs.org/doi/10.1021/acsomega.2c07326
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881416/#:~:text=Curcumin%20is%20the%20most%20important,of%20the%20root%20(30).