Just curious if your doc has suggested trying something other than hydroxyurea? Dad also had ET, and his platelets ran high and fluctuated a lot. He was put on a HU/anagrelide combo that was somewhat more effective. There really weren't any treatments other than that at the time. I have talked to ET patients who progressed to myelofibrosis (MF) and did well on Jakafi. It isn't used much for ET, but might be indicated when HU just isn't doing the job very well. In Europe, interferon/Pegasys is more commonly used, especially for younger patients, than in the U.S., where cost of newer drugs puts them out of reach for some.