Hi! @beachbabe & Sue:

I actually have been wondering the same question regarding the safest & effective medication to take while on Anastrozole to prevent osteoporosis! I started taking Anastrozole since 1/18/24; had experienced loads of awful side effects such as: joints pain, trigger fingers, muscle pain all over body, etc., about 2 days after. Due to the fact that I declined the radiation treatments against my oncologists' recommendation, so I decided to tough it out and continue taking AI. Had been given Zometa infusion on 2/15/24, developed rash, itchy skin, and all sorts of flu-like symptoms on the same night. Again, I thought I simply had to tough myself out to get through whatever side-effects that might come, thus I strived on. Unfortunately for me, I experienced acute lower back pain suddenly on 2/25; shockingly for me, I discovered a soft "bump" grown exactly on my lumbar spine on the night of 2/26. The medical oncologist saw me on 2/28 and ordered a MRI Lumbar Spine with & without IV contrast to rule out the potential metastatic disease. Thank God (!) that MRI confirmed it is not caused by cancerous cells, but also revealed many spinal issues such as: lumbar lordosis, lumbar retrolisthesis on various levels, etc., and my medical oncologist now refering me to orthopedic spinal surgeon. Surely I don 't know which medications causing these spinal issues, because my medical oncologist did not confirm nor dispute any of these sudden occuring issues are caused by medications that they prescribed.

Yes, I truly wish somebody points us to the correct path to take the best medicine striving forward!

Best wishes to you all, my comrades fighting the disease of cancers!