My doctor says platelets should be between 140 - 450. I have heard different ranges but they are all close. I have been a member of the Polycythemia Vera JAK2 V617F club since 2018. After high platelets (658) in a blood test, my doctor had me do a whopper blood test that cost me $1,200.00 out of pocket after my insurance paid. That is when I had the official PV verdict. I have been on Hydra for 6 years now with minimal side effects. Just get tired in the afternoon. I wish you the best, watching the grass grow in Kentucky, the heartland of America.