@julchilds @suecreader I have not tried R-ALA and from my very brief internet review, it seems to be an antioxidant. However, since there is some indication it helps with peripheral neuropathy, I wouldn't dismiss this out of hand. But, and this is a big BUT, there are some serious possible side effects from taking this supplement. My approach has always been to proceed with the least invasive or harmful approach and always proceed with caution. Since R-ALA is a "supplement", it isn't medically vetted by the FDA. Julchilds, I am so happy that you are experiencing some relief from RLS with VitD3. Tell your MD as possibly your experience will be used to help others.

As to whether RLS always gets worse??? I have found it is totally controlled with VitD3 and if it does get worse, I will try increasing the D3 before trying something else. I have been dealing with this for 8 or 10 years and it is controlled by D3 without getting worse or needing more D3.