So, your sisters were helped by Vitamin D too? You're so right about the anecdotal evidence not being considered - I think doctors stick to the adage "it's not scientifically based evidence." that's why your post is so valuable . . . . . just like the thalamus connection whereby it doesn't work for me to do the CBT approach recommended by Rochester (for people with insomnia--and RLS is NOT the same as insomnia ....as I keep telling people who have the latter). In CBT, people are supposed to have quiet time before bed, no blue lights from TV or other devices, if unable to sleep, get up and do something boring and not at all stimulating. However, I've tried this approach for six months, and it never worked as my RLS just got worse if I tried to read a dull or dry book or do a crossword. With the thalamus connection, the representative from Relaxis indicated that the thalamus needs to stay busy -- so, after walking two-three hours and being even more exhausted, sometimes laying down (if my RLS let me) and watching TV allowed me to drift off to sleep. He also recommended listening to something that would be engaging like rock music via headphones . . . . that has worked for some people as told by him (again anecdotal evidence). Thanks for more detail about your story . . . I already take 2000 mg of Vit D but will increase that if Neupro stops working. I don't like to add too much at one time since then it is hard to tell which approach is the one that is most successful.