I am 73 YO female with RLS. My Mom had it and several of my sisters have it. Three of us have found doses of 1000 to 4000 IUs of Vitamin D have been very helpful in controlling RLS symptoms. Certain medications exacerbate the problem, such as Benadryl or other such meds, Ambien and other sleep meds. Gabapentin does help but that med comes with its own set of side effects. For me, 4000 IU's of Vitamin D saved my mental health.