@06111945cc I also have hypothyroidism and wonder why my osteoporosis is so bad. I also am very petite and was underweight for a long time. I was very active physically until the fractures got in the way. I asked my endo about cutting back on my Levothyroxine to increase Estrogen and help my bones. He said I wasn't going to get any. I keep thinking that Estrogen is the answer and may use that after I am done taking Tymlos.