I was tested for restless leg syndrome. My dr asked if I was taking antihistamines ( which I took on and off). For me-every time I took BENADRYL my legs would get 'restless' and my muscles would tighten and cramp up. By not taking it I was fine. Odd huh!! Lynn

I agree Jim. We all have to take the information we are given and find what works best for us. They actually want me to take 2- 300 mili pills, 3 times per day. The ones at night for my legs and the rest of the dosage to posibly help with some deep brain seizures they think i might be having. Gabapentin was originally created to be a seizure medication.
That is odd, Lynn. I had been taking Tylenol PM to help me sleep at night, and my doctor told me that it has Benadryl in it and not to take it any more for sleep. That could have been making my RLS worse. Good to know, Thanks!

You know, Lynn, years ago I used to take sleep aids that contained benedryl - and finally decided the benedryl was actually "wiring" me! Learned to stay away from that stuff! We are all so different, my husbanc takes a benedryl at night for itching and sleeps like a baby!!!

@barbarn, we learned the hard way that the wired effect was what happened with our oldest son. The only people needing sleep after giving it to him for allergy problems were me and my wife. He would have not been as hyper with a bag full of gummi bears! You are spot on about how everyone reacts differently to drugs and gene mapping is helping us understand exactly why.

I have only taken Diphenhydramine Hcl (Benadryl) for allergy purposes, @barbarn -- it's like my rescue medication if I have an allergy "attack" that goes above what my usual allergy medications can relieve. I have experienced the same thing as you -- I've been wired and wide-eyed for hours after taking it, though many people report sleepiness.