Tamoxifen and mental health

I have early multicentric lobular breast cancer w/ a positive lymph node but have declined all estrogen blockers, and radiation. I must have reviewed over 500 peer reviewed articles and 50? medical presentations on UT and concluded that the documented adverse effects would ironically increase my risk in other ways. Beyond that, I'm disabled from a connective tissue disorder--getting worse w/ age, and genetic--and so taking it would put me in bed all day to what? Have more years in bed in all day?

Instead of titrating estrogen blocker dose to a woman's weight and any kind of baseline estrogen measurement to at least establish basic efficacy, the same amount is given to someone w/ a BMI of 40 and or 21. Women are told their symptoms aren't real--placebo effect! It's in your head! The depression and fatigue induced by these drugs then preclude exercise & social activities (two major preventative factors for recurrence) and contribute to inevitable weight gain. Excess weight carries excess estrogen and is a known risk factor for recurrence as it promotes metabolic syndrome.

No guidance is given to patients about reducing glucose (carbs, sugar, fruit juice) that feed cancer cells--instead, pasta and whole grain breads are GREAT. It's "Mediterranean"--which remains undefined to this day. No info on intermittent fasting being linked in dose dependent manner w/ lower recurrence in breast cancer (published in 2016) and seen in so many other cancers.

And then pain? In an atmosphere of sadistic undertreatment of pain--especially women's--with even Stage 4 cancer patients being undertreated b/c of an insane hysteria about opioid misuse that was misrepresented from the outset (it was due to illegal drugs, not prescriptions)--estrogen blockers cause DOCUMENTED HARM TO CONNECTIVE TISSUE. At least 600 pubs are on the joint pain caused by these drugs, including many studies using MRI, biological and genetic analysis to demonstrate that YES, damage is being done to these joints because estrogen is so critical to joint health.

So---everyone can make their own choice. If I were naturally resilient, younger and healthy, have young kids, have a great community, no comorbidities, awesome physicians and pain control should I need it, AND, a later stage tumor--I could see using a lower dose. But it's not worth it for me and I've got the citations to stand up to any doctor telling me it is.

It can save your life! Tamoxifen is part mind over matter. Good luck.

Thank you for your reply.

I'm too on Tamoxefen & having extreme brain fog, headaches, depression, poor cognition & concentration...etc...so have been researching & think we should all be very wary of these problems. Studies I've read are not extensive or totally conclusive but are showing up a lot of issues.
Please read this link
https://ascopubs.org/doi/10.1200/JCO.2008.21.3553#:~:text=Conclusion,in%20postmenopausal%20patients%20with%20BC

The link below is of another study & also highlights the problems & issues of Tamoxifen saying "Tamoxifen is
shown to decrease performance on visuospatial, visual, and verbal memory tasks".

Please read below link
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11010888/#:~:text=While%20tamoxifen%20is%20effective%20at,3%2C5%2C6%5D

How has the Effexor been working for you?

I'm 82. I had a lumpectomy, chemo and radiation at 79. I refused Tamoxifen. I remembered how horrible emotionally I was during menopause. I saw my oncologist lately. He looked at my blood work and said that he doesn't expect my cancer to come back.

Hi
I believe everyone has the right to make their own choice but myself I will not take any of these medications I am erpr positive her two negative stage zero they tried to push this on me I tried tamoxifen for 6 days it was the worst 6 days of my life I almost blacked out driving it affected my brain horrifically in researching these medications I don't understand they cause so much harm to a woman's body. My oncologist agreed with me that it was not worth the risk because I have osteoporosis already and a heart condition. I want quality of life.

Hi
Wow really I disagree with that statement. My oncologist told me with my health conditions it's a very hi risk medication for myself. Not at all worth the risk. I took it for 6 days and almost blacked out driving from the horrid side effects. Its in no way mind over matter. I had migraine for 6 days severe fatigue , naseau, brain fog. So glad to be off it.

Hello, can you please give us some sites where we can read more into this?
I did read a bit about tamoxifen and learned about brain fog, which I am scared of. I was diagnosed with DCIS stage 0 and will be having lumpectomy on July 11. I am ER+ so the Dr already gave me all heads up that meds will be part of my treatment.
Any help is appreciated!