Hi @taisaint, All of this information can be found in National Institute of Health, Pub Med articles and pharmaceutical websites by typing in Hydroxurea. This is a medication that’s been used reliably to treat certain blood cancers and conditions for a couple of decades. There can be risks and side effects to all meds, even supplements. So I’d like to caution you about reading into some of these articles if you feel the outcome might prevent you from taking a medication such as Hydrea.

I agree, knowledge is power. I like to research and know what I’m taking as well. But I also had a very aggressive form of leukemia and would not be alive today had I not taken all the meds with the black box warning label. They worked and I’m alive and healthy because of these drugs.
Here are links to the mechanism of action for Hydroxyurea:
https://pubmed.ncbi.nlm.nih.gov/1641648/
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https://go.drugbank.com/drugs/DB01005
From our prior conversations, I know you have both PV and ET with a mutation in the JAK2 gene, causing an overproduction of both red blood cells and platelets. There may be foods and supplements which can impact platelet and red blood levels. However, if your levels are elevated because of a genetic mutation that won’t be impacted or helped by foods or supplements. The rate of production of cells would be driven by the mutation.

I think I already gave you information about the JAK2 mutation and the myeloproliferative diseases it can cause. But if I didn’t here’s a link to a great tutorial about MPNs and the JAK2 gene.
https://www.healthline.com/health/cancer/myeloproliferative-disorders#symptoms
I know you’d really like to try a natural route. Honestly, we all would! Sometimes we don’t have choices. In your case, I think it’s really important to try the medication that your doctor has suggested to get the proliferation of the blood cells under control.
Have you consulted with an MPN (myeloproliferative neoplasm) specialist?