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Stubbornly elevated ALT and AST

Transplants | Last Active: Feb 23 10:16am | Replies (8)

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Hi and thank you for your reply!
My doctor has done multiple ultrasounds on my abdomen and apparently there are no issues with my gallblader/biliary ducts. How was your primary biliary cholangitis actually diagnosed? Are there specific blood markers that need to be done?

RA has been excluded a long time ago. But I have osteoporosis and I am on medication for that condition. According to my doctor, those meds do not cause elevated liver enzymes, and it is not listed on the package leaf as a side effect.

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Replies to "Hi and thank you for your reply! My doctor has done multiple ultrasounds on my abdomen..."

Good morning
My PBC was diagnosed via routine blood tests. My family doctor thought it was arthritis related so sent me to a rheumatologist. The rheumatologist looked at my numbers and said no this is not arthritis and he sent me to a liver specialist so I was diagnosed when I was about 50 and I had my liver transplant in 2020.

Hi @sophie93. My liver remains highly reactive to anything since having months of chemo and a bone marrow transplant. However, for months my AST and ALT were happy as larks. Then out of the blue in 3 months time between blood draws, my numbers shot up again! That required me to go back to monthly draws for a few months. Everything reversed again and my numbers are great.
The only variable was that a few months before my alarming blood draw, I had started taking a daily OTC multivitamin for women! My doctor didn’t feel that would be the issue but it was suggested I stop anyway. And my gosh, the next 3 tests were perfect!! It was the vitamin A in the multivitamin that caused my liver to flair. No where is that listed as a side effect and I only took one per day! So just because it’s not listed, doesn’t mean it can’t happen.

There is a link between having liver disease and developing osteoporosis. https://pubmed.ncbi.nlm.nih.gov/29479832/

Which leads me to wonder if there can be link between treating osteoporosis and potential for liver issues? I found this article for you that validates your thoughts.


Our livers can be very sensitive but they can also heal and regenerate quickly. It might be worth another chat with your doctor about your bone loss and liver numbers. Have you seen an endocrinologist about your osteoporosis?