1. < Diabetes & Endocrine System

Is there a connection between b6 toxicity and thyroid issues?

Posted by lbishop @lbishop, May 5, 2023

In the fall, I developed a series of odd symptoms, including vertigo, then tinnitus, brain fog, fatigue, muscle spasms, etc. as well as some of the common symptoms of hypothyroidism, including hair loss, constipation, etc. After seeing multiple doctors, one suggested I get my B levels checked. All were normal except for B6, which are extremely high (>250, with normal upper range of 21). I don't take supplements, really. An occasional multi-vitamin. At the same time, my TSH levels are on the rise. My normal is below 3 and they are now at close to 4.5. I've been taking NP Thyroid for more than 10 years at a very low dose. I can't figure out why my B6 levels would be so high, or how they might relate to other test results.

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smutchler | @smutchler | Feb 22 5:14am
In reply to @chrystinea "You have to take Pyridoxal 5 phosphate(active b6). This is the active version of b6, it..." + (show)
@chrystinea

You have to take Pyridoxal 5 phosphate(active b6). This is the active version of b6, it is safe in large doses unlike inactive form pyridoxine. Active and inactive both work against each other in the body. Large amounts of pyridoxine will actually make you more deficient in b6 even though it shows up in your blood stream, you have to check your blood CELL. Half the population cannot convert pyridoxine into the active form Pyridoxal 5 Phosphate that goes into the cell. Unable to convert pyridoxine, it builds up in your system. The more active form you take the more it lowers the inactive form. I had every symptom of b6 deficiency which is also the same as the b6 toxicity and I landed myself in and out of the hospital. No one knew what was wrong with me. After learning this I took fully active forms of b vitamins including extra active b6 and each day I took it I got progressively better, I went from being bed bound and having seizures , swollen thyroid nausea every symptoms to feeling amazing after taking the active form. Before this My blood showed I was high in b6 in my blood stream but it wasn’t making its way into the cell, which is where genes come into play because if you have the MTHFR gene you don’t have the enzyme to convert inactive to active form. Causing deficiency or toxicity. Half the population has this gene. It’s hard to find a fully activated b complex but Klair Labs has one you can find on Amazon. Magnesium is needed to activate b vitamins. Glycinate is a good one. Hope this helps

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This is inaccurate information. P5P can cause B6 toxicity. A significant amount of research regarding B6 Toxicity, including Thyroid issues, can be read at understandingb6toxicity.com

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smutchler | @smutchler | Feb 22 5:28am
In reply to @cehunt57 "@johnbishop thank you for the information on B6 in regards to thyroid. I have heard that..." + (show)
@cehunt57

@johnbishop thank you for the information on B6 in regards to thyroid. I have heard that vitamin B has an impact on neuropathy but had no idea there was any connection to thyroid issues.

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Hi Cheryl. I posted on John's as well. I encourage you to learn more about B6 Toxicity, including thyroid issues, by visiting understandingb6toxicity.com.

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smutchler | @smutchler | Feb 22 5:30am
In reply to @proudx "What blood test did you take? Mine shows the active form p5p as high in blood..." + (show)
@proudx

What blood test did you take? Mine shows the active form p5p as high in blood stream so I’m obviously converting it.

What is your source of info that taking high amounts of p5p is safe? This seems like dangerous advice.

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Thank you for your comment. This is indeed not safe. Research has shown tgat P5P is as dangerous as taking any form of B6 or providing

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Mentor
John, Volunteer Mentor | @johnbishop | Feb 22 7:26am
In reply to @smutchler "Thank you for your comment. This is indeed not safe. Research has shown tgat P5P is..." + (show)
@smutchler

Thank you for your comment. This is indeed not safe. Research has shown tgat P5P is as dangerous as taking any form of B6 or providing

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Thought I would post the link for you since new members are not allowed to post links for a short period of time.

--- Understanding B6 Toxicity: https://understandingb6toxicity.com/

Another good site which is older but much easier to read and understand (for me at least).
--- Easy Immune System Health - Find Out the Real Reason For Vitamin B6 Toxicity: https://www.easy-immune-health.com/vitamin-b6-toxicity.html

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smutchler | @smutchler | Feb 22 7:43am

Thank you John. Very helpful. Yes, there is a lot of info at the website. I also get a lot of support from the Understanding B6 Toxicity using Western Research Facebook page. There are approximately 7500 members. The Protocol recommended is directionally a positive life change. Hydration, exercise and diet changes.

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1 reply
smutchler | @smutchler | Feb 22 7:45am
In reply to @smutchler "Thank you John. Very helpful. Yes, there is a lot of info at the website. I..." + (show)
@smutchler

Thank you John. Very helpful. Yes, there is a lot of info at the website. I also get a lot of support from the Understanding B6 Toxicity using Western Research Facebook page. There are approximately 7500 members. The Protocol recommended is directionally a positive life change. Hydration, exercise and diet changes.

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Also, I have attached an "awareness" card. Australia and EU have stricter guidelines regarding reco.mended DV for B6.
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proudx | @proudx | May 10 5:16pm

I continue to experience high b6 p5p blood levels from food alone and have not figured out. I have hypothyroidism and recently developed hand erosive arthritis

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abid | @abid | May 12 8:14am

What is b6 p5p? May be your erosive arthritis is rheumatoid arthritis as it is also an autoimmune disease.

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donnakerbel | @donnakerbel | Jun 3 1:36pm
In reply to @proudx "I have the EXACT problem. B6 toxicity from food alone and have hypothyroidism. Your story sounds..." + (show)
@proudx

I have the EXACT problem. B6 toxicity from food alone and have hypothyroidism. Your story sounds exactly like mine. I tried cutting back on b6 foods, done tons of labs, taken tbyroid medication, etc. I’ve posted my journey on a Facebook group.

I believe I have a rare form of hypothyroidism called central hypothyroidism that is driving it.

I also have peripheral neuropathy

Anyway we can connect to compare notes and try and find a solution?

If links are allowed I could send you my documented journey and comments from the Facebook group.

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I was diagnosed with high B6 toxicity 20 months ago. I follow a protocol from a FB group eating the RDA of b6 daily and working on not going under or over it. I’ve recently developed irregular heart beat (I’ve had this is the past), my neuropathy is worse and I am checking out my thyroid. No matter what I eat my face starts tingling. I am really not feeling well.

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