Hi, I am over 30 years out from my transplant. I rejected 3 weeks post transplant. I know prednisone is very hard on liver. I started in 1990 on Tacrolimus and rejected at 25 yrs. Increased Tacrolimus dose for a while. Numbers came down. Everyone is different. I know I was offered 2nd immunosuppression drug but my team at Pittsburgh said Tacrolimus is used for rejection. I chose to stay on Tacrolimus and not add 2nd drug. Too many side effects. Glad you are taking charge of your own health by joining group. Praying that you will overcome.