1. < Colorectal Cancer

Latest Signatera test went from negative to 1.02

Posted by cjay @cjay, Feb 2 12:38pm

My 4th Signatera test results just came back, and for the first time since my resection surgery it’s a positive result of 1.02
I have my first CT scan (since my treatment ended) next week.
Trying to stay calm and positive until the scan results come back, but of course that’s difficult.
Does anyone have any experience similar? And what happened after that positive test?
🤞🙏

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reidroberts | @reidroberts | Feb 13 1:24pm
In reply to @cjay "Thanks Colleen, it’s been a week that I’ve been living with it, and I’m not as..." + (show)
@cjay

Thanks Colleen, it’s been a week that I’ve been living with it, and I’m not as emotional wrecked as I originally was. I had my scan on Friday - showed no masses or signs of metastatic disease, but I know from what Reid told me things might be too minuscule to show up until the next scan. I have an appointment with my oncology team tomorrow after work, and a phone meeting Wednesday with my surgeon at MUSC. I should know more after those.
I did have a phone conference with a genetic counselor at Signatera, and she was helpful with understanding the numbers a bit more and some good general knowledge. Right now I’m hoping the circulating tumor dna is residual, rather than a new occurrence. And hoping for some new drug besides the FOLFOX if I do need chemo.
🙏🤞
I will update after I get some news.

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No signs of metastatic disease is great news. Hopefully it is confined in the colon and has not broken out into the lymph node system. I had 1 lymph node that tested positive for colon cancer and that was all it took, in my case, to start small spots on the lung and liver. I am grateful with all the testing that we were able to catch this early before becoming a bigger problem.

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1 reply
cjay | @cjay | Feb 13 3:06pm
In reply to @reidroberts "No signs of metastatic disease is great news. Hopefully it is confined in the colon and..." + (show)
@reidroberts

No signs of metastatic disease is great news. Hopefully it is confined in the colon and has not broken out into the lymph node system. I had 1 lymph node that tested positive for colon cancer and that was all it took, in my case, to start small spots on the lung and liver. I am grateful with all the testing that we were able to catch this early before becoming a bigger problem.

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I had 26 lymph nodes removed- 16 were cancerous.
So I’m not positive it’s not a case of the scan not registering anything because it’s too minuscule. (I remember that happened to you)
My appointment was changed to tomorrow afternoon. Staying positive

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1 reply
reidroberts | @reidroberts | Feb 13 3:38pm
In reply to @cjay "I had 26 lymph nodes removed- 16 were cancerous. So I’m not positive it’s not a..." + (show)
@cjay

I had 26 lymph nodes removed- 16 were cancerous.
So I’m not positive it’s not a case of the scan not registering anything because it’s too minuscule. (I remember that happened to you)
My appointment was changed to tomorrow afternoon. Staying positive

Jump to this post

Good luck tomorrow. When my Signatera test showed up positive the second time with a very small number, I was hoping it was just a false reading. Unfortunately my Oncologist told me they have never had a false result with Signatera tests. And with the low numbers I was hoping it would take awhile to develop before I had to remove it. However, the tests elevated quickly, within 2-3 months, where we could see the spots on a scan and then have them removed. This sucked but after all said and done, I'm fortunate to find these early. It's much easier to remove a 1/4 inch spot than a 3 inch tumor. So, my next question for the Doctors is if the Signatera test come back positive in the future with a very low reading, should we do a few chemo rounds to knock it out before it can develop into a very small spot.

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