Hi @sue58 Thank you for sharing your husband's story. I was hoping to get in ten years of wait and watch but it looks like that won't happen. I am very happy to hear that eventually the correct meds for him worked, but yes how unfortunate to have to deal with the tick bite. My wbc is at 119 and lymphocyte count almost matches that. There is definitely lots of hope for people with cll. I asked about entering a trial, but unfortunately there were not enough people in my area in the same category as me, although the doctor said she may be able to take a second look at it. I am torn anyway about limping along the way I am or starting treatment because of the numerous possible side effects. What kind of side effects did your husband have on Imbruvica? I will have to look into Venclexta.