Thank you both for your responses! I have had osteoporosis for a long time, and that is my main objection to long-term prednisone use. I do take Fosamax and watch my calcium and vit D intake. My pcp is on top of this issue. It’s good to know Crohn’s can be managed on less powerful drugs than biologics, and I may be a candidate for a sulfa or ASA based drug (although they didn’t work for me in the years after diagnosis). If I made this transition, I could use Actemra for the PMR, but not while on inflixamab. My rheumatologist has mentioned Methotrexate as a steroid-sparing treatment. My asthma is really my biggest issue at this moment, even though I am on 40 mg of prednisone, which is the usual dose for treating a flare. I get repeat labs this week, and will ask for a D level. Thanks for that suggestion. This is all very complicated and I am trying to wrap my head around all treatment options.