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Natural high levels of B12 and B6

Neuropathy | Last Active: Aug 31 6:22pm | Replies (110)

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@chme

I wish I had someone who understands this issue better.
I have good B12 levels and B1 levels but high B6. 66.2

I’ve found a b supplement without b6 and just started taking. It’s from Desert Harvest. B complex without b6.

Will wait to retest blood level for 6 months. Seems to be a good deal of at least references to b6 toxicity but no information on what a blood level for toxicity would be.

Thank you.

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Replies to "I wish I had someone who understands this issue better. I have good B12 levels and..."

Hi @chme, I think your question may not have a clear definitive answer mostly because I think it may be a little different for each of us due to other factors including age. This article may help explain it:
--- Vitamin B6 - Fact Sheet for Consumers: https://ods.od.nih.gov/factsheets/VitaminB6-Consumer/

This reference mentions toxicity levels:
"Vitamin B6 (pyridoxine) causes neuropathy at intakes of 1000 mg per day or more, which is about 800 times the daily intake from foods. There have also been occasional reports of toxicity at intakes of 100-300 mg per day. The US authorities set the no-observed-adverse-effect-level at 200 mg per day and the safe upper limit at 100 mg per day. A report of neurotoxicity in 2 patients who had taken 24 mg and 40 mg of vitamin B6 per day respectively, may be coincidence rather than a true toxic effect of such relatively low doses. However, physicians need to remain alert to high intakes of vitamin B6 as a cause of unexplained neuropathy."
--- How much vitamin B6 is toxic?: https://pubmed.ncbi.nlm.nih.gov/16320662/