When first diagnosed 20+ years ago, m y platelets were around 1800....no symptoms, caught in a thorough blood workup. My GP sent me to a oncology hemotologist, who put me on Agrylin (anagrelide before it was generic). I never had any problem with it, as long as I take the dosage regularly (.5 mg morning and night currently). When that doctor retired ten years in, the next, new doc the Regal/Lakeside group referred terrorized me for about 2 months insisting I should have taken hydroxyurea....Finally got different authorization with Dr who said, if it works, bhy change? That's my experience!! Platelets hover below 400, see the doc every 6 months now (I'm 73), was seeing him annually in my my 60s.